Visual field defect associated with vigabatrin: observational cohort study.
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چکیده
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the surviving 4741 patients, 89 reports were followed up with ophthalmologists. The ophthalmologists consider that 30 (83%) of the 36 cases for which there is objective evidence of visual field defect are probably or possibly related to vigabatrin. In four cases they did not know whether the defect was related to vigabatrin treatment, and in the remaining two cases the defect was considered not...
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OBJECTIVE To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy u...
متن کاملVigabatrin-induced peripheral visual field defects in patients with refractory partial epilepsy.
PURPOSE Vigabatrin can cause retinopathy, resulting in bilateral visual field constriction. Previous analyses of results from a prospective, observational study assessing vigabatrin-induced visual field constriction (described below) employed a partially subjective interpretation of static perimetery. To affirm these previous findings through more objective, quantitative methodology, we now rep...
متن کاملRetinal function abnormalities in patients treated with vigabatrin.
OBJECTIVE To evaluate central and peripheral retinal function in patients treated with vigabatrin, an antiepileptic drug associated with peripheral visual field constriction (VFC). METHODS Six patients with epilepsy treated with vigabatrin as add-on therapy for at least 3 years were included in this observational case series. All patients underwent a clinical ophthalmologic examination, color...
متن کاملA controlled study of vigabatrin and visual abnormalities.
AIMS To assess the visual function in epileptic patients who have received vigabatrin; to compare this with the visual function in similar epileptic patients who have never received vigabatrin; to investigate whether the severity of visual field defect (VFD) is related to the dose of vigabatrin; to consider other factors that may correlate with the severity of VFD. METHODS 21 consecutive pati...
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OBJECTIVE The aim of the present study was to assess visual alterations in a population of Argentine patients treated with the antiepileptic drug vigabatrin. METHODS Twenty patients receiving vigabatrin and 15 patients receiving carbamazepine were examined with automated perimetry using a Humphrey 120-point full screening strategy. In addition, scotopic flash electroretinograms were performed...
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ورودعنوان ژورنال:
- BMJ
دوره 319 7218 شماره
صفحات -
تاریخ انتشار 1999